The land frontier with the Republic of Panama is approximately 266 km long. Negotiations with Panama (1906-1924) began some time after the separation of the Department of Panama in 1903, and the final agreement was reached in 1924.

• "Treaty of Limits between the Republic of Colombia and the Republic of Panama", signed in Bogota on 20 August 1924 by the plenipotentiaries Jorge Velez of Colombia and Nicolas Victoria J. of Panama.